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Yong Woo Lee, Seonghee Shim, Joon Mo Kim, Chul Young Choi, Ki Ho Park; The effect of anthocyanins and ginko biloba extract treatment in patients with open-angle glaucoma depending on the presence of diabetes mellitus. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4460.
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Anthocyanins and ginko biloba extract (GBE) are considered beneficial for various vascular disease. This study was performed to evaluate the effect of anthocyanins and GBE on visual function in patients with open-angle glaucoma depending on the presence of diabetes mellitus(DM).
Retrospective study by chart review of 410 individuals (271 men and 139 women) with open-angle glaucoma who were treated with anthocyanins (n = 184) /GBE (n = 116) or no medication (n = 110). Humphrey Visual Field(HVF) test, logarithm of the minimal angle of resolution best-corrected visual acuity (logMAR BCVA), and intraocular pressure, blood pressure, and fasting blood glucose were determined before and at the end of treatment. Data was divided into two groups, depending on presence of DM, and change of visual function parameters in each group were analyzed.
In the open-angle glaucoma patients without DM (n=254), the mean change of logMAR BCVA was -0.07(±0.24) in anthocyanins treatment group, 0.004(±0.06) in GBE group and 0.05(±0.20) in control(p<0.001). In the open-angle glaucoma patients with DM (n=156), the mean change of logMAR BCVA was -0.03(±0.15) in anthocyanins treatment group, 0.03(±0.08) in GBE group and 0.06(±0.09) in control(p=0.005). Other changes in visual function parameters were not consistently correlated with anthocyanins or GBE treatment.
Systemic administration of anthocyanins appeared to be helpful in improving BCVA in some individuals with open-angle glaucoma regardless of diabtes mellitus.
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