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Tomofumi Tani, Taiji Nagaoka, Takafumi Yoshioka, Akitoshi Yoshida; Measurement Of Retinal Blood Flow and Retinal Oxygen Tension During Acute Decreasing Systemic Blood Pressure In Cats. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4667.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate retinal arteriolar blood flow (RBF) and retinal oxygen tension (PO(2)) during decreases in systemic blood pressure (BP) in cats.
The effect of acute decreased systemic blood pressure on RBF and PO(2) on near the arteriolar were assessed with laser Doppler velocimetry (CLBF model 100, Canon) and oxygen microelectrodes (POE-10N, BRC). The systemic BP was decreased over 5 minutes with continuous withdrawal of blood from the descending aorta at 24% of total blood volume using a syringe pomp (Model 11 Plus Advanced, Harvard Apparatus). Ocular perfusion pressure (OPP) was calculated as OPP = mean arterial BP (MABP) - IOP.
The RBF was maintained until 70mmHg of OPP and started to decrease (P<0.01) below 60 mmHg of OPP. The PO(2) was also maintained until 70mmHg of OPP and started to decrease (P<0.01) below 60 mmHg of OPP.
These results suggest that RBF may be maintained more than 70 mmHg of OPP. The PO(2) seems to reflect RBF changes during acute decreasing systemic BP in cats.
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