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Camila Netto, Sung Chul Park, Wendy Kirkland, Rafael Furlanetto, Yiyi Liu, Jeffrey Liebmann, Robert Ritch; In Vivo Structure of the Schlemm’s Canal and the Collector Channels in Eyes with Chronic Angle-Closure Glaucoma Compared to Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4823.
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© ARVO (1962-2015); The Authors (2016-present)
To characterize in vivo structure of the Schlemm’s canal (SC) and the collector channels (CC) in eyes with chronic angle-closure glaucoma (CACG) compared to normal eyes.
Serial horizontal enhanced depth imaging optical coherence tomography (EDI OCT) B-scans were obtained in the nasal and temporal limbal areas from CACG patients and normal subjects (81 scans per 15x5 degree rectangle; interval between scans, ~35 µm; Fig A and B). The cross-sectional area of the SC was measured in each EDI OCT B-scan (Fig C). After three-dimensional SC reconstruction, SC volume was calculated for each eye. The CCs connected to SC (Fig D) were counted.
Nine CACG eyes (9 patients; mean age, 72±10 years) and 11 normal eyes (11 subjects; mean age, 28±5 years) were included. In CACG eyes, the SC and CC were mostly obliterated in the areas with high peripheral anterior synechiae (PAS; Fig E) and were mostly open but smaller than those in normal eyes in the areas with no or low PAS (Fig F). The mean cross-sectional SC area was significantly smaller in the CACG than in the normal eyes (863±611 µm2 vs. 3512±1228 µm2; p<0.001; Fig G), as was the SC volume (0.005±0.003 mm3 vs. 0.020±0.006 mm3; p<0.001). The number of the CCs was significantly smaller in the CACG than in the normal eyes (2.3±1.3 vs. 6.5±1.6; p<0.001; Fig H).
SC appears smaller and connected to fewer open CCs in CACG eyes than in normal eyes. In CACG eyes, circumferential aqueous flow is compromised in areas with high PAS.
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