June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Glaucoma Clinician (GC) Color Stereophoto (CSphoto) Rim Estimation Compared to Colocalized Spectral Domain Optical Coherence Tomography (SDOCT) Minimum Rim Measurements
Author Affiliations & Notes
  • Robert Kinast
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Ruojin Ren
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Helen Koenigsman
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Hongli Yang
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Stuart Gardiner
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Juan Reynaud
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Steven Mansberger
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Brad Fortune
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Shaban Demirel
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Claude Burgoyne
    Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Research Institute, Portland, OR
  • Footnotes
    Commercial Relationships Robert Kinast, None; Ruojin Ren, None; Helen Koenigsman, None; Hongli Yang, None; Stuart Gardiner, Allergan (R); Juan Reynaud, None; Steven Mansberger, Merck (R), Alcon (C), Allergan (C), Allergan (F), Merck (F), Santen (C), Glaukos (C); Brad Fortune, Heidelberg Engineering, GmbH (F), Carl Zeiss Meditec, Inc (F); Shaban Demirel, Carl Zeiss Meditec (F), Heidelberg Engineering (R), Heidelberg Engineering (F); Claude Burgoyne, Heidelberg Engineering (F), Heidelberg Engineering (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4827. doi:
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      Robert Kinast, Ruojin Ren, Helen Koenigsman, Hongli Yang, Stuart Gardiner, Juan Reynaud, Steven Mansberger, Brad Fortune, Shaban Demirel, Claude Burgoyne; Glaucoma Clinician (GC) Color Stereophoto (CSphoto) Rim Estimation Compared to Colocalized Spectral Domain Optical Coherence Tomography (SDOCT) Minimum Rim Measurements. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4827.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To compare GC CSphoto neuroretinal rim width (RWGC) and area (RAGC) to colocalized SDOCT minimum rim width (MRWSDOCT) and area (MRASDOCT) in 53 eyes of 53 glaucoma and glaucoma suspect patients.

 
Methods
 

For each eye, same day CSphotos and SDOCT data sets (Spectralis, Heidelberg Engineering) were colocalized using the SDOCT IR image. Bruch’s membrane opening (BMO) and the internal limiting membrane (ILM) were hand delineated within the SDOCT data sets and MRWSDOCT/MRASDOCT were calculated based on the minimum distance between BMO and the ILM within 12 sectors based on the fovea - BMOcentroid (FoBMO) axis (Figure 1). Five GCs independently delineated the disc (DM) and rim margin (RM) within the colocalized CSphotos generating RWGC and RAGC estimates within the same FoBMO sectors. For each sector of each eye, the magnitude of each GC RW and RA estimate as well as their difference from MRWSDOCT and MRASDOCT were recorded. Generalized estimating equations were used to assess the significance of GC versus SDOCT differences accounting for inter-clinician correlations for the same eye.

 
Results
 

Between GC differences in mean RWGC and mean RAGC (Figure 1) were substantial. While mean RWGC was significantly larger than BMO-MRW (p≤0.003) in every FoBMO segment and RAGC was greater than MRASDOCT superior nasally, RAGC was less than MRASDOCT (Figure 1) inferior temporally. GC versus SDOCT discordance for both RW and RA (Figure 1) were substantial in all quadrants.

 
Conclusions
 

SDOCT/CSphoto colocalization and a common, FoBMO-based regionalization strategy has allowed the first precise comparisons between glaucoma clinician and SDOCT rim assessment. Variability among the five GCs in this study was substantial and lead to wide GC versus SDOCT discordance. The source and clinical importance of these differences are under study.

   
 
Figure 1. Five GC’s individual and averaged RWGC and RAGC compared to colocalized MRWSDOCT and MRASDOCT. Variability plots of GC and SDOCT differences organized by 12 sectors based on the FoBMO axis.
 
Figure 1. Five GC’s individual and averaged RWGC and RAGC compared to colocalized MRWSDOCT and MRASDOCT. Variability plots of GC and SDOCT differences organized by 12 sectors based on the FoBMO axis.
 
Keywords: 627 optic disc • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical  
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