June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Glaucoma Assessment using Retinal Topography by Scanning Laser Ophthalmoscope Imaging
Author Affiliations & Notes
  • Maarten Huijbregtse
    i-Optics BV, The Hague, Netherlands
  • Dirk De Brouwere
    i-Optics BV, The Hague, Netherlands
  • Michiel Mensink
    i-Optics BV, The Hague, Netherlands
  • Footnotes
    Commercial Relationships Maarten Huijbregtse, i-Optics BV (E); Dirk De Brouwere, i-Optics bv (E); Michiel Mensink, i-Optics bv (I), i-Optics bv (P), i-Optics bv (S)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2013, Vol.54, 4847. doi:
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      Maarten Huijbregtse, Dirk De Brouwere, Michiel Mensink; Glaucoma Assessment using Retinal Topography by Scanning Laser Ophthalmoscope Imaging. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4847.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

A 3D topographic reconstruction of the retinal surface can be a helpful aid in diagnosing and monitoring the occurrence and progression of retinal pathologies like glaucoma. In this study, we used a compact confocal Scanning Laser Ophthalmoscope (cSLO) to assess the presence of glaucoma in a mixed group of subjects through retinal topography of the optic nerve head.

 
Methods
 

For this study, a zero-dilation compact cSLO (EasyScan, i-Optics, The Netherlands) was modified to acquire stacks of retinal images at different focal depths. The confocal nature of the camera enables the 3D reconstruction of the retinal surface from a depth-resolved image stack after image registration. Besides ten healthy eyes, ten glaucomatous eyes were recruited. Subjects were excluded from the study when the optical media were unclear. The 45 degree nasal field was imaged twice for all eyes. Reconstructed topographic maps were rendered and presented to two experienced glaucoma graders.

 
Results
 

Both graders referred the glaucomatous eyes with a strong agreement to the diagnosis as communicated in each patient’s medical record. Sensitivity and specificity were in line with the outcomes known in the standard practice for glaucoma diagnosis. Additionally, no significant difference could be observed when comparing the two different topographic reconstructions taken in each eye.

 
Conclusions
 

The results indicate that retinal topography can be implemented in a compact cSLO camera, in a precise enough manner to use it for diagnosing and monitoring glaucoma. We believe this will allow healthcare providers to prevent progression of visual loss in glaucomatous patients with treatments in the early stages of the pathology.

 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 627 optic disc  
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