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Hongting Liu, Millena Bittencourt, Owhofasa Agbedia, Ahmadreza Moradi, Yasir Sepah, Daniel Ferraz, Mohamed Ibrahim, Raafay Sophie, Mehreen Ansari, Quan Dong Nguyen; Longitudinal Changes in Retinal Sensitivity among Patients with Maculopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5026.
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To investigate longitudinal changes in retinal sensitivity among patients with maculopathy with stable visual acuity (VA) and central retinal thickness (CRT).
In this prospective study,16 patients with maculopathy and no change in VA (≤ 5 letters change in ETDRS score) and CRT (≤ 20 μm in spectral-domain optical coherence tomography (SD-OCT)) between 2 visits (interval: 2-6 months) were evaluated. Disease entities included diabetic macular edema, age related macular degeneration, central serous retinopathy, Stargardt's disease and idiopathic macular hole. Retinal sensitivity was assessed using the Spectral-OCT/SLO microperimetry (MP) (Optos Inc, Scotland, UK) at both visits. The test pattern was a standardized polar 3 grid which consists of 28 points within 11° from the fovea. The mean change and variance in retinal sensitivity for all patients was compared to the MP inter-session variation of 10 patients with retinopathies.
A total of 700 points from 25 eyes (16 patients) with maculopathy were analyzed. The mean age of subjects was 53 years (SD ±16). The results are summarized in the table. The overall variance between the two visits (6.0dB) was significantly greater than the inter-session variance (2.4dB) (Mann Whitney Test, p=0.008).
Microperimetry may capture subtle functional changes in maculopathy patients with stable visual acuity and no change in central retinal thickness. Further studies with larger sample size are indicated to validate the observed results.
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