June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Relationship between Visual Function and Optical Coherence Tomography features in Early Age-related macular degeneration (AMD)-Early Markers Observational Study
Author Affiliations & Notes
  • Ruth Hogg
    Center for Vision and Vascular Science, Queen's University Belfast, Belfast, United Kingdom
  • George Murphy
    Center for Vision and Vascular Science, Queen's University Belfast, Belfast, United Kingdom
  • Giovanni Staurenghi
    Eye Clinic - Department of Clinical Science, “Luigi Sacco”- Sacco Hospital, II School of Ophthalmology - University of Milan, Milan, Italy
  • Chiara Rosina
    Eye Clinic - Department of Clinical Science, “Luigi Sacco”- Sacco Hospital, II School of Ophthalmology - University of Milan, Milan, Italy
  • Rufino Silva
    Faculty of Medicine., University of Coimbra, Coimbra, Portugal
  • Ana Rita Santos
    Faculty of Medicine., University of Coimbra, Coimbra, Portugal
  • Usha Chakravarthy
    Center for Vision and Vascular Science, Queen's University Belfast, Belfast, United Kingdom
  • Footnotes
    Commercial Relationships Ruth Hogg, Novartis (F), Novartis (C); George Murphy, None; Giovanni Staurenghi, Ocular Instruments (P), GSK (C), Novartis (C), Alcon (C), Allergan (C), Bayer (C), Roche (C), Heidelberg Engineering (C), OD-OS (C), QLT (C), Optos (C); Chiara Rosina, None; Rufino Silva, Thea (C), Novartis (C), Bayer (C), Allergan (C), Alimera (C); Ana Rita Santos, None; Usha Chakravarthy, Bayer (C), Novartis (F), Neovista (C), Oraya (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5028. doi:
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      Ruth Hogg, George Murphy, Giovanni Staurenghi, Chiara Rosina, Rufino Silva, Ana Rita Santos, Usha Chakravarthy, ; Relationship between Visual Function and Optical Coherence Tomography features in Early Age-related macular degeneration (AMD)-Early Markers Observational Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5028.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate the relationship between visual function parameters and tomographic metrics.

 
Methods
 

Study sample: 105 patients (53 males, 52 females) with unilateral advanced AMD from 3 Centres (Milan, Coimbra and Belfast) aged 52-93 years. Study Eye=Fellow eye without advanced neovascular disease. Best corrected distance acuity (BCVA) and near acuity (NVA), reading speed adjusted for print size (reading index; RI) and low-luminance acuity (SKILL test) were measured. High density macular raster scans on the Heidelberg were obtained. Trained graders measured the neuroretinal thickness (NRT) and choroidal thickness (CT) at the foveal centre and evaluated the continuity of the following layers (ganglion cell layer GCL, inner segment/outer segment junction IS/OS, external limiting membrane ELM, photoreceptor layer PRL and retinal pigment epithelium RPE). Univariate and logistic regression analyses were employed to examine relationships between function and morphology.

 
Results
 

NRT was associated with BCVA (r=0.24 p=0.024); CT with reduced (SKILL score) (r=-0.4 p<0.001). Retinal layer continuity showed relationships with functional tests. External Limiting Membrane continuity was associated with DVA (p=0.006), NVA (p=0.021) and Reading index (p=0.020). IS/OS junction continuity was associated with DVA (p=0.007), NVA (p=0.03) and SKILL score (p=0.050). Photoreceptor layer continuity was associated with Reading index (p=0.039). RPE layer continuity was associated with SKILL score (p=0.003).

 
Conclusions
 

Significant associations exist between stressors of macular visual function such as near acuity and low luminance acuity and tomographic markers of retinal and choroidal morphology.

 
Keywords: 412 age-related macular degeneration • 754 visual acuity • 550 imaging/image analysis: clinical  
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