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William White, Mae Hu, Glenn Huang, Tan Pham, Faina Karasina, Aaron Lee, Maria Gorlina, Vernon Wong; In Vivo Pharmacokinetics of Injectable, Intravitreal, Sustained-Release Latanoprost Formulations. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5047.
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© ARVO (1962-2015); The Authors (2016-present)
To study the in vivo pharmacokinetics of injectable, intravitreal, sustained-release latanoprost formulations
In vivo anterior chamber drug levels were measured in New Zealand White rabbits receiving single doses of one of two formulations of sustained-release latanoprost administered by intravitreal injection. Aqueous humor samples were obtained weekly and analyzed for latanoprost acid concentrations using high-performance liquid chromatography with mass spectrometry.
Sustained levels of latanoprost acid in the aqueous humor were demonstrated for 3 to 7 months in animals injected with single doses of sustained-release latanoprost formulations. The sustained-release formulation containing 559 µg of latanoprost demonstrated sustained levels of anterior chamber latanoprost acid which decreased to an average latanoprost acid aqueous humor level of 17.5 pg/mL on day 84. The sustained-release formulation containing 1118 µg of latanoprost demonstrated sustained anterior chamber levels of latanoprost acid which decreased to an average latanoprost acid aqueous humor level of 19.1 pg/mL on day 231.
In vivo anterior chamber levels of latanoprost acid were sustained for up to 7 months and were well-tolerated in rabbits receiving sustained-release latanoprost formulations injected intravitreally.
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