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SungHo Lee, Dongkyu Lee, Yong Song You, Soon Hyun Kim, Chang Yeol Lee, Hyungil Jung, Sung Jin Lee, Oh Woong Kwon; A hollow metal microneedle reduce reflux in intravitreal injections. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5075.
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The study aimed to evaluate the reduction of reflux in intravitreal injections using a minimally invasive hollow metal microneedle.
Rabbit twenty eyes undergoing intravitreal injection were allocated into two groups to compare the vitreal reflux after injection of 0.02 ml of 0.1% sodium fluorescin (Alcon) using a 30G needle and a hollow metal microneedle (five millimeter long, hundred outer diameter, fifty inner diameter and fifteen degree beveled angle). The amount of drug reflux was estimated by measuring amount of fluorescin in an absorbent cotton swab and the width of subconjunctival fluorescence staining area.
The mean measured reflux of volume was statistically less with hollow metal microneedle (0.27 SD ± 0.25 ng for swab absorbed fluorescin; 3.4mm SD ± 0.5 for width of subconjunctival fluorescence staining area) than undergoing the 30G needle injection (1.51 SD ± 0.63 ng for swab absorbed fluorescin; 8.2 mm SD ± 0.7 for width of subconjunctival fluorescence staining area) .
Analyses of vitreal reflux showed that hollow metal microneedle prevent vitreal reflux drugs after intravitreal injection than 30G needle. Moreover, microneedle provide accuracies in drug administration, lesser scleral damage and the risk of complication after repeat injections.
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