June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Scotopic Spatial Summation in Retinopathy of Prematurity (ROP)
Author Affiliations & Notes
  • Jena Tavormina
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Harvard Medical School, Boston, MA
  • Ronald Hansen
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Harvard Medical School, Boston, MA
  • Anne Moskowitz
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Harvard Medical School, Boston, MA
  • Anne Fulton
    Ophthalmology, Boston Children's Hospital, Boston, MA
    Harvard Medical School, Boston, MA
  • Footnotes
    Commercial Relationships Jena Tavormina, None; Ronald Hansen, None; Anne Moskowitz, None; Anne Fulton, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5080. doi:
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    • Get Citation

      Jena Tavormina, Ronald Hansen, Anne Moskowitz, Anne Fulton; Scotopic Spatial Summation in Retinopathy of Prematurity (ROP). Invest. Ophthalmol. Vis. Sci. 2013;54(15):5080.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To study scotopic spatial summation in children with a history of retinopathy of prematurity (ROP). Full-field electroretinograms give evidence of photoreceptor and post-receptor dysfunction in ROP subjects but provide no spatial information. Spatial summation is thought to depend on pooling of information by the post-receptor neural retina.

Methods: To determine the critical diameter for complete spatial summation, we are measuring rod-mediated thresholds for detection of brief-duration stimuli ranging from 0.4 to 10 degrees in diameter. Dark-adapted subjects with a history of ROP (N=5; median age 13 years) and age-similar controls (N=4; median age 14 years) have been tested. A two-alternative spatial forced choice method was used in conjunction with a staircase procedure. Stimuli were presented 20 degrees to the right or left of a central fixation target.

Results: The median critical diameter for complete summation was 1.61 (range: 1.36 to 1.91) degrees in the ROP subjects and 1.30 (range 1.19 to 1.36) degrees in the controls. Critical diameter was significantly larger in ROP subjects (Fisher’s Exact Test, p=0.048). Interestingly, for the largest stimuli, thresholds in ROP subjects did not differ significantly from those in controls.

Conclusions: These results suggest a coarser spatial grain in the ROP retina. Pooling over a larger region may allow ROP subjects to achieve a normal threshold.

Keywords: 706 retinopathy of prematurity • 688 retina • 641 perception  
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