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Kulawan Rojananuangnit, John Johnstone, Massimo Fazio, Mark Clark, Cynthia Owsley, Brandon Smith, Christopher Girkin; Racial variation in deep optic nerve head structures visualized with SD-OCT. Invest. Ophthalmol. Vis. Sci. 2013;54(15):51.
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To determine associations between variations in optic nerve head connective tissue visible with SD-OCT images with both age and race [African descent (AD), European Descent (ED)].
SD-OCT images from 171 normal eyes (66 eyes from 34 AD and 105 eyes from 53 ED) were included. 3D optic nerve head reconstructions were obtained. Delineation of the SD-OCT images was done using Devers Eye Institute Multiview software in 24 radial sagittal sections (Burgoyne C). A best fitting ellipse was computed using principal component analysis to define Bruch’s Membrane Opening (BMO) and this was taken as a reference for further analysis. A mesh was reconstructed from the point cloud for the anterior surface of lamina cribrosa (LC) and internal limiting membrane (ILM). We then measured the distance from a uniform sampling of the BMO ellipse to the LC mesh and ILM and calculated the mean and maximum depths for the lamina cribrosa depth (LCD; distance from BMO reference to LC mesh) and the cup depth (CD; distance from BMO reference to ILM). We looked at the variation in CD and LCD across racial strata (ED or AD) adjusted for age, central corneal thickness (CCT), axial length, and BMO area using mixed effects models with generalized estimating equations.
The AD group showed larger disc area (2.1±0.5, 1.8±0.3 mm2, p<0.0001) and deeper cup depth (p value: 0.046) than the ED group after adjusted for all relevant confounds. (Table 1)
Increased cup depth as defined by the optic nerve surface tissues differed between AD and ED subjects, however, there was no significant difference in laminar cribrosa depth, suggesting these differences are largely due to difference in overlying pre-laminar surface tissues.
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