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Tae Kwann Park, Joo Hyun, SangIl An, Young-Hoon Ohn; Prognostic Value of Photopic Negative Response in Retinal Vein Occlusion after Anti-VEGF treatment. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5123.
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© ARVO (1962-2015); The Authors (2016-present)
To investigated the potential of optical coherence tomography (OCT) and photopic negative response (PhNR) for predicting visual outcome after intravitreal bevacizumab in patients with macular edema secondary to branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO).
Fifty consecutive patients with macular edema secondary to unilateral retinal vein occlusion (RVO) who were treated with three times of 6 weeks interval intravitreal bevacizumab were enrolled. LogMAR visual acuity (Va), OCT and PhNR were done before and 4 weeks after first and third injection. Stepwise multiple regression analysis were conducted between pre-treatment Va, central retinal thickness (CRT), PhNR amplitude, PhNR relative amplitude (affected eye/unaffected-fellow eye, % presentation) and post-treatment Va at 4 weeks after the third injection. The predictive values of pre-treatment parameters for good visual outcome (0.2 ≤ LogMAR Va) were assessed using receiver-operating characteristics (ROC) analysis.
In multiple regression analysis, pre-treatment Va (β=0.512, P=0.001) and PhNR relative amplitude (β=-0.383, P=0.012) were correlated significantly with post-treatment Va. In ROC analysis, pre-treatment Va showed a 81% sensitivity and 89% specificity for predicting good visual outcome, at a cutoff value of 0.61 LogMAR. Pre-treatment PhNR relative amplitude demonstrated a 86% sensitivity and 80% specificity for predicting good visual outcome, at a cutoff value of 44.7%.
The PhNR relative amplitude can be a useful prognostic factor for visual outcome after intravitreal bevacizumab therapy in patient with macular edema secondary to RVO. Patients with larger pre-treatment PhNR relative amplitude with better pre-treatment Va showed a better post-treatment visual outcome.
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