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Belquiz Nassaralla, Anelise Lago, Larissa Rossana Stival, Joao Nassaralla; Corneal sensitivity changes following cross-linking for progressive lower stage keratoconus. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5260.
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To evaluate corneal sensitivity changes following corneal cross-linking (CXL) in patients with progressive lower stage keratoconus.
Thirty eight eyes of 19 patients (11 women, 8 men) were included in a prospective, nonrandomized clinical study. Mean patient age was 22 years (range, 18-26 years). Inclusion criteria were low stage bilateral progressive keratoconus, transparent cornea and thinnest corneal thickness ≥ 440 µm. Using the Cochet-Bonnet esthesiometer central corneal sensitivity was measured preoperatively, after 7 days, and once a month after surgery until recovery of the baseline preoperative level. Normal levels of central corneal sensitivity were considered above 40mm.
Corneal sensitivity gradually returned to preoperative levels in all treated eyes. Mean central corneal sensitivity was 52.2, 24.0, 38.2, 42.4, 50.0, and 52.4 mm before surgery, at 7 days, and at 1, 2, 3 and 4 months after surgery, respectively. Normal levels of corneal sensation, but not baseline preoperative levels, were noted 2 months after surgery. Preoperative levels were observed 3 months after surgery.
Our results suggest that after CXL for progressive lower stage keratoconus, central corneal sensitivity is decreased for as long as 3 months.
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