June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Corneal Endothelial Cell Density Following Transepithelial Collagen Cross-Linking
Author Affiliations & Notes
  • Michael Raciti
    Rush University Medical Center, Chicago, IL
  • Randy Epstein
    Rush University Medical Center, Chicago, IL
    Chicago Cornea Consultants, Chicago, IL
  • Parag Majmudar
    Rush University Medical Center, Chicago, IL
    Chicago Cornea Consultants, Chicago, IL
  • William Trattler
    Center For Excellence In Eye Care, Miami, FL
  • Footnotes
    Commercial Relationships Michael Raciti, None; Randy Epstein, alcon (C), bausch and lomb (C), tear science (C); Parag Majmudar, None; William Trattler, CXLO (I), CXLUSA (C), CURVERIGHT (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5263. doi:
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    • Get Citation

      Michael Raciti, Randy Epstein, Parag Majmudar, William Trattler, ; Corneal Endothelial Cell Density Following Transepithelial Collagen Cross-Linking. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5263.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the change in corneal endothelial cell density after transepithelial collagen cross-linking (CXL) for the treatment of corneal ectasia.

Methods: Transepithelial CXL was performed using riboflavin 0.1% followed by UV-A light for 30 minutes in patients with keratoconus, pellucid degeneration, or LASIK-induced ectasia. Only eyes with corneal thickness greater than or equal to 400µm were treated. Endothelial cell counts were measured pre-CXL and at least 6 months post-CXL using noncontact specular microscopy.

Results: Seventy three eyes were evaluated. The mean corneal endothelial cell density was 2522 +/- 513 cells/mm2 pre-CXL and 2674 +/- 452 cells/mm2 post-CXL (P=0.063).

Conclusions: This study showed no significant change in corneal endothelial cell density after transepithelial CXL by riboflavin/ultraviolet-A treatment for corneal ectasia.

Keywords: 574 keratoconus • 481 cornea: endothelium  
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