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Michael Raciti, Randy Epstein, Parag Majmudar, William Trattler, ; Corneal Endothelial Cell Density Following Transepithelial Collagen Cross-Linking. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5263.
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To evaluate the change in corneal endothelial cell density after transepithelial collagen cross-linking (CXL) for the treatment of corneal ectasia.
Transepithelial CXL was performed using riboflavin 0.1% followed by UV-A light for 30 minutes in patients with keratoconus, pellucid degeneration, or LASIK-induced ectasia. Only eyes with corneal thickness greater than or equal to 400µm were treated. Endothelial cell counts were measured pre-CXL and at least 6 months post-CXL using noncontact specular microscopy.
Seventy three eyes were evaluated. The mean corneal endothelial cell density was 2522 +/- 513 cells/mm2 pre-CXL and 2674 +/- 452 cells/mm2 post-CXL (P=0.063).
This study showed no significant change in corneal endothelial cell density after transepithelial CXL by riboflavin/ultraviolet-A treatment for corneal ectasia.
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