June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
DIGS and ADAGES: Relationship Between Rates of Binocular Visual Field Loss and Vision-Related Quality of Life in Glaucoma
Author Affiliations & Notes
  • Renato Lisboa
    Ophthalmology, Hamilton Glaucoma Center, La Jolla, CA
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • Yeoun Sook Chun
    Ophthalmology, Hamilton Glaucoma Center, La Jolla, CA
    Ophthalmology, Chung-Ang University, Seoul, Republic of Korea
  • Linda Zangwill
    Ophthalmology, Hamilton Glaucoma Center, La Jolla, CA
  • Robert Weinreb
    Ophthalmology, Hamilton Glaucoma Center, La Jolla, CA
  • Peter Rosen
    Ophthalmology, Hamilton Glaucoma Center, La Jolla, CA
  • Jeffrey Liebmann
    Opthtalmology, New York Eye and Ear Infirmary, Ney York, NY
  • Christopher Girkin
    Ophthalmology, University of Alabama, Birmingham, AL
  • Felipe Medeiros
    Ophthalmology, Hamilton Glaucoma Center, La Jolla, CA
  • Footnotes
    Commercial Relationships Renato Lisboa, None; Yeoun Sook Chun, None; Linda Zangwill, Carl Zeiss Meditec Inc (F), Heidelberg Engineering GmbH (F), Optovue Inc (F), Topcon Medical Systems Inc (F), Nidek Inc (F); Robert Weinreb, Aerie (F), Alcon (C), Allergan (C), Altheos (C), Amakem (C), Bausch&Lomb (C), Carl Zeiss-Meditec (C), Genentech (F), Haag-Streit (F), Heidelberg Engineering (F), Konan (F), Lumenis (F), National Eye Institute (F), Nidek (F), Optovue (C), Quark (C), Solx (C), Topcon (C); Peter Rosen, None; Jeffrey Liebmann, Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Allergan, Inc. (F), Carl Zeiss Meditech, Inc (F), Heidelberg Engineering, GmbH (F), Topcon Medical Systems, Inc. (F), National Eye Institute (F), New York Glaucoma Research Institute (F), SOLX, Inc. (C), Bausch & Lomb, Inc (C), Diopsys, Inc. (C), Diopsys, Inc. (F), Merz, Inc. (C), Glaukos, Inc. (C), Quark, Inc. (C); Christopher Girkin, SOLX (F), Heidelberg Engineering (F); Felipe Medeiros, Carl-Zeiss (F), Heidelberg Engineering (F), Topcon (F), Alcon (F), Allergan (F), Sensimed (F), Reichert (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5329. doi:
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      Renato Lisboa, Yeoun Sook Chun, Linda Zangwill, Robert Weinreb, Peter Rosen, Jeffrey Liebmann, Christopher Girkin, Felipe Medeiros, ; DIGS and ADAGES: Relationship Between Rates of Binocular Visual Field Loss and Vision-Related Quality of Life in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5329.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the relationship between binocular rates of visual field change and vision-related quality of life (VRQOL) in glaucoma.

 
Methods
 

The study included 796 eyes of 398 participants that had diagnosed or suspected glaucoma followed for an average of 7.3 ± 2.0 years. Subjects were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES). VRQOL was evaluated using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) at the last follow-up visit. Integrated binocular visual fields (BVF) were calculated from the monocular fields of each patient. Linear regression of mean deviation (MD) values was used to evaluate rates of visual field change during the follow-up period. Logistic regression models were used to investigate the relationship between abnormal VRQOL and rates of visual field change, while adjusting for potentially confounding socio-economic and demographic variables.

 
Results
 

Thirty-two patients (8.0%) had abnormal VRQOL as determined by the results of the NEI VFQ-25 questionnaire. Subjects with abnormal VRQOL had significantly faster rates of BVF change than those with normal VRQOL (-0.18 db/year vs. -0.06 dB/year, respectively; P < 0.001). Rates of BVF change were significantly associated with abnormality in VRQOL (OR = 1.31 per 0.1dB/year faster; P = 0.038), after adjustment for confounding variables.

 
Conclusions
 

Patients with faster rates of BVF change were at higher risk of reporting abnormal VRQOL. Assessment of rates of BVF change may provide useful information in determining risk of functional impairment in glaucoma.

 
Keywords: 434 binocular vision/stereopsis • 669 quality of life • 760 visual search  
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