June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Punctate Inner Choroidopathy characterization by Enhanced Depth Imaging-Optical Coherence Tomography: Quantitative analysis of Retinal and Choroidal layers by manual segmentation
Author Affiliations & Notes
  • Noa Fernandez Ledo
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Javier Zarranz-Ventura
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Dawn Sim
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Pearse Keane
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Catherine Egan
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Praveen Patel
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Mark Westcott
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Richard Lee
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Adnan Tufail
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Carlos Pavesio
    Medical Retina, Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships Noa Fernandez Ledo, None; Javier Zarranz-Ventura, None; Dawn Sim, None; Pearse Keane, None; Catherine Egan, Bayer (S), Oculogics (S), Novartis (S), Allergan (S), Novartis (F); Praveen Patel, Allergan (R), Bayer (C), Novartis UK (C), Heidelberg UK (R), Topcon UK (R), Thrombogenics (C); Mark Westcott, None; Richard Lee, Genentech (C); Adnan Tufail, Allergan (C), Bayer (C), GSK (C), Oculogics (C), Pfizer (C), Thrombogenics (C), Amakem (C), Heidelberg Engineering (R), Novarits/Alcon (C), Sanofi/Genzyme (C); Carlos Pavesio, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5378. doi:
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      Noa Fernandez Ledo, Javier Zarranz-Ventura, Dawn Sim, Pearse Keane, Catherine Egan, Praveen Patel, Mark Westcott, Richard Lee, Adnan Tufail, Carlos Pavesio; Punctate Inner Choroidopathy characterization by Enhanced Depth Imaging-Optical Coherence Tomography: Quantitative analysis of Retinal and Choroidal layers by manual segmentation. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5378.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

: To determine quantitatively the thickness and volume of retinal and choroidal layers in fovea and macula in a series of Punctate Inner Choroidopathy (PIC) patients and determine their relationship with clinical data collected from medical records.

 
Methods
 

: Enhanced depth imaging OCT images from patients diagnosed with PIC and quiescent status of disease were collected in two tertiary referral Uveitis clinics at Moorfields Eye Hospital for 5 months. Quantitative analysis included retinal, choroidal, Sattler medium vessel layer and Haller large vessel layer thickness and volume determination with a custom OCT analysis software (OCTOR). Clinical data collected included age, gender, refractive status, type of disease (typical vs atypical), duration of disease and BCVA.

 
Results
 

: 2242 uveitic patients were screened, 46 patients diagnosed with PIC were identified, and 35 eyes (35 patients) had EDI-OCT images that met the inclusion criteria. Mean retinal thickness and volume was 256.04±32.9 µm and 10.16±1.41 mm3, mean choroidal thickness and volume was 210.52±103.44 µm and 8.13±3.60 mm3. Typical PIC presented significantly thicker retina (270.66±23.22 vs 243.73±35.36 µm, p:0.014) and choroid than atypical PIC (249.42±95.10 vs 177.77±100.98 µm, p:0.039). High myopic PIC eyes presented significantly thinner choroid, Haller’s, and Sattler’s layers thickness and volume than low myopic eyes (p<0.001). Refraction was significantly correlated with both foveal and macular choroidal thickness (r:0.72, p<0.001; r:0.73, p<0.001) and volume (r:0.72, p<0.001; r:0.60, p<0.001). In subgroup analysis, duration of disease was significantly correlated to retinal thickness and volume (r:-0.53, p:0.018; r:-0.47, p:0.040) in non-high myopic eyes. A strong significant correlation was observed between BCVA and retinal thickness (r:-0.40, p:0.030) and volume (r:-0.40, p:0.027) in fovea of PIC eyes

 
Conclusions
 

Typical PIC patients presented thicker retina and choroid than atypical cases. Refractive status appears as the main predictor of choroidal thickness and volume measures, and retinal values are correlated with BCVA and with duration of disease in non-highly myopic PIC eyes

     
Keywords: 746 uveitis-clinical/animal model • 688 retina • 419 anatomy  
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