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Noa Fernandez Ledo, Javier Zarranz-Ventura, Dawn Sim, Pearse Keane, Catherine Egan, Praveen Patel, Mark Westcott, Richard Lee, Adnan Tufail, Carlos Pavesio; Punctate Inner Choroidopathy characterization by Enhanced Depth Imaging-Optical Coherence Tomography: Quantitative analysis of Retinal and Choroidal layers by manual segmentation. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5378.
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© ARVO (1962-2015); The Authors (2016-present)
: To determine quantitatively the thickness and volume of retinal and choroidal layers in fovea and macula in a series of Punctate Inner Choroidopathy (PIC) patients and determine their relationship with clinical data collected from medical records.
: Enhanced depth imaging OCT images from patients diagnosed with PIC and quiescent status of disease were collected in two tertiary referral Uveitis clinics at Moorfields Eye Hospital for 5 months. Quantitative analysis included retinal, choroidal, Sattler medium vessel layer and Haller large vessel layer thickness and volume determination with a custom OCT analysis software (OCTOR). Clinical data collected included age, gender, refractive status, type of disease (typical vs atypical), duration of disease and BCVA.
: 2242 uveitic patients were screened, 46 patients diagnosed with PIC were identified, and 35 eyes (35 patients) had EDI-OCT images that met the inclusion criteria. Mean retinal thickness and volume was 256.04±32.9 µm and 10.16±1.41 mm3, mean choroidal thickness and volume was 210.52±103.44 µm and 8.13±3.60 mm3. Typical PIC presented significantly thicker retina (270.66±23.22 vs 243.73±35.36 µm, p:0.014) and choroid than atypical PIC (249.42±95.10 vs 177.77±100.98 µm, p:0.039). High myopic PIC eyes presented significantly thinner choroid, Haller’s, and Sattler’s layers thickness and volume than low myopic eyes (p<0.001). Refraction was significantly correlated with both foveal and macular choroidal thickness (r:0.72, p<0.001; r:0.73, p<0.001) and volume (r:0.72, p<0.001; r:0.60, p<0.001). In subgroup analysis, duration of disease was significantly correlated to retinal thickness and volume (r:-0.53, p:0.018; r:-0.47, p:0.040) in non-high myopic eyes. A strong significant correlation was observed between BCVA and retinal thickness (r:-0.40, p:0.030) and volume (r:-0.40, p:0.027) in fovea of PIC eyes
Typical PIC patients presented thicker retina and choroid than atypical cases. Refractive status appears as the main predictor of choroidal thickness and volume measures, and retinal values are correlated with BCVA and with duration of disease in non-highly myopic PIC eyes
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