June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
The effect of sulindac liposome on inflammation induced corneal neovascularization
Author Affiliations & Notes
  • Jun-Sub Choi
    Ophthalmology & Visual Science, Catholic Univ Korea Coll of Med, Seoul, Republic of Korea
  • Choun-Ki Joo
    Ophthalmology & Visual Science, Catholic Univ Korea Coll of Med, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships Jun-Sub Choi, None; Choun-Ki Joo, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5401. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Jun-Sub Choi, Choun-Ki Joo; The effect of sulindac liposome on inflammation induced corneal neovascularization. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5401.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To investigate the effect of topical sulindac liposome on inflammatory induced corneal neovascularization.

Methods: Sprague-Dawley male (250g) rats were used for alkali burn model. After alkali injuries using 1 N NaOH, the control group (n=10) received topical PBS four times a day for 2 days. The other study groups received topical sulindac-liposome. The corneal neovascularization were evaluated using slit lamp biomicroscopy. And tissue sections were analyzed for inflammatory cell infiltration. Inflammatory cells were confirmed by immunohistochmistry for F4/80.

Results: The sulindac liposome inhibited corneal neovasculariztion and inflammatory response after corneal injury. In light microscopic findings, the corneal thickness was increased and many polymorphonuclear leukocytes infiltrated in the corneal stroma in the control group. In immunohistochemical study, in sulindac-liposome treated group, the F4/80 positive cells were detected lower than control group (p<0.05, respectively).

Conclusions: The sulindac is anti-inflammatory drugs. The topical sulindac liposome has beneficial effect on inflammatory induced corneal neovascularization. Supported: This study was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea. (A092258)

Keywords: 609 neovascularization • 557 inflammation  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×