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Trupti Patil, Rajesh Sasikumar, Sathi Devi, Glaucoma; Are thinner corneas associated with reduced hystersis?. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5655.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the relationship between central corneal thickness (CCT) and corneal biomechanical properties in Asian Indian eyes with glaucoma.
In this prospective observational comparative study, glaucoma patients on treatment were assigned to two groups based on CCT; CCT< 500μ (group A) and >500μ (group B). Goldman applanation tonometry (GAT) was measured in all using a single calibration checked device. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured using the Ocular Response Analyzer (ORA). The deformation amplitude (DA) of the cornea was measured using the CorVis non-contact tonometer. Pearson’s correlation coefficient was used to evaluate correlation between parameters. Univariate and multivariate regression analysis was used to determine the relationship between the various parameters
A total of 107 eyes (76 patients) were enrolled; 60 eyes had CCT<500μ. Majority had open angle glaucoma (62%). The average CCT of group A was 474.7±18.7 μ compared to that of group B (534.6±24.1 μ) (p<0.01). The average CH (7.29 mm Hg in group A vs 7.68 mmHg in group B, p>0.05) and DA (1.01mm vs 1.04mm, p>0.05) was not significantly different, but CRF (8.34mm Hg vs 9.43 mm Hg) showed significant difference (p=0.03). CH showed a weak positive relationship with CCT in both groups (r=0.22-0.25, p<0.05). Univariate analysis with CH as the dependent variable in group A showed significant association with CCT, IOPcc, CRF and GAT (p<0.05) in group A; only IOPcc and CRF showed association in multivariate analysis.
CH, which measures viscous damping of cornea was not significantly different between the two groups; CH and DA do not appear to be influenced by CCT. CRF was significantly different between the two groups, suggestive of reduced overall resistance in thinner cornea.
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