June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Central Corneal Thickness and IOP Response to Topical Ocular Hypotensive Medication in the Low-pressure Glaucoma Treatment Study
Author Affiliations & Notes
  • Christopher Teng
    Ophthalmology, Einhorn Clinical Research Center, New York Eye & Ear Infirmary, New York, NY
    Ophthalmology, NYU School of Medicine, New York, NY
  • Gustavo De Moraes
    Ophthalmology, Einhorn Clinical Research Center, New York Eye & Ear Infirmary, New York, NY
    Ophthalmology, NYU School of Medicine, New York, NY
  • Jeffrey Liebmann
    Ophthalmology, NYU School of Medicine, New York, NY
  • David Greenfield
    Ophthalmology, Bascom Palmer Eye Institute, Palm Beach Gardens, FL
  • Robert Ritch
    Ophthalmology, Einhorn Clinical Research Center, New York Eye & Ear Infirmary, New York, NY
    Ophthalmology, New York Medical College, Valhalla, NY
  • Theodore Krupin
    Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL
    The Chicago Center for Vision Research, Chicago, IL
  • Footnotes
    Commercial Relationships Christopher Teng, None; Gustavo De Moraes, None; Jeffrey Liebmann, Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Allergan, Inc. (F), Carl Zeiss Meditech, Inc (F), Heidelberg Engineering, GmbH (F), Topcon Medical Systems, Inc. (F), National Eye Institute (F), New York Glaucoma Research Institute (F), SOLX, Inc. (C), Bausch & Lomb, Inc (C), Diopsys, Inc. (C), Diopsys, Inc. (F), Merz, Inc. (C), Glaukos, Inc. (C), Quark, Inc. (C); David Greenfield, National Eye Institute (R), Carl Zeiss Meditec (R), Optovue (R), Heidelberg Engineering (R), Allergan (C), Alcon (C), Merz (C), Quark (C), SOLX (C), Biometric Imaging (C), Senju (C); Robert Ritch, None; Theodore Krupin, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5662. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Christopher Teng, Gustavo De Moraes, Jeffrey Liebmann, David Greenfield, Robert Ritch, Theodore Krupin, ; Central Corneal Thickness and IOP Response to Topical Ocular Hypotensive Medication in the Low-pressure Glaucoma Treatment Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5662.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: The Ocular Hypertension Treatment Study (OHTS) showed that IOP response to medical therapy was associated with central corneal thickness (CCT) and that eyes with thinner corneas have a more substantial IOP lowering than those with thick corneas. We aimed to investigate whether CCT correlated with IOP response to topical ocular hypotensive medication in the Low-pressure Glaucoma Treatment Study (LoGTS).

Methods: 253 LoGTS participants were analyzed. The groups were divided into tertiles based on CCT, and the 85 patients with the thickest corneas (Group A) and 85 patients with the thinnest corneas (Group B) were compared. Various parameters were analyzed, including mean IOP during the diurnal curve prior to treatment, follow up IOP peak, trough, mean and fluctuation, absolute and percent IOP reduction, and mean deviation (MD) rate of progression (dB/yr).

Results: As expected, Group A had a thicker CCT than Group B (580.2±23.4 vs. 508.6±20.6 microns, p<0.001). During the diurnal curve, Group A had a higher mean IOP than Group B (16.1±2.3 vs. 15.3±2.6, p=0.05). Follow up mean IOP was lower in Group B than Group A (13.4±2.4 vs. 14.4±2.1 mmHg, p=0.005) as was IOP trough during follow up (10.9±2.4 vs. 11.7±2.5, p=0.037). There was no difference in IOP peak during follow up (p=0.179), IOP fluctuation (p=0.277), absolute IOP reduction (p=0.41) or percent IOP reduction (p=0.20). There was no difference in the mean deviation slopes between Group A and B (-0.14±0.82 vs. -0.26±1.01, p=0.38).

Conclusions: Unlike the OHTS findings, there was no correlation between IOP response to medical therapy and CCT in eyes with low pressure glaucoma.

Keywords: 568 intraocular pressure • 615 neuroprotection  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×