June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Risk Factors of Astigmatism in the Vision in Preschoolers (VIP) Study
Author Affiliations & Notes
  • Jiayan Huang
    University of Pennsylvania, Philadelphia, PA
  • Gui-Shuang Ying
    University of Pennsylvania, Philadelphia, PA
  • Maureen Maguire
    University of Pennsylvania, Philadelphia, PA
  • Graham Quinn
    Children’s Hospital of Philadelphia, Philadelphia, PA
  • Marjean Kulp
    Ohio State University, Columbus, OH
  • Elise Ciner
    Salus University, Elkins Park, PA
  • Lynn Cyert
    Northeastern State University, Tahlequah, OK
  • Deborah Orel-Bixler
    University of California, Berkeley, CA
  • Bruce Moore
    New England College of Optometry, Boston, MA
  • Footnotes
    Commercial Relationships Jiayan Huang, None; Gui-Shuang Ying, None; Maureen Maguire, Inspire Pharmaceuticals (F), Amakem (F), IDx LLC (F), Merck (C); Graham Quinn, None; Marjean Kulp, None; Elise Ciner, None; Lynn Cyert, None; Deborah Orel-Bixler, None; Bruce Moore, EyeNetra Inc. (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5691. doi:
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      Jiayan Huang, Gui-Shuang Ying, Maureen Maguire, Graham Quinn, Marjean Kulp, Elise Ciner, Lynn Cyert, Deborah Orel-Bixler, Bruce Moore, ; Risk Factors of Astigmatism in the Vision in Preschoolers (VIP) Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5691.

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Abstract
 
Purpose
 

To determine demographic and refractive risk factors for astigmatism among Head Start preschoolers in the Vision in Preschoolers (VIP) Study.

 
Methods
 

Head Start preschoolers (aged 3 to 5 years, over-represented with vision problems) were enrolled into the multi-center, cross-sectional VIP Study. All children underwent comprehensive eye examinations, including monocular visual acuity (VA), stereoacuity, and cycloplegic refraction. Astigmatism was defined by the presence of > 1.5 diopters (D) cylinder in either eye, measured with cycloplegic refraction. The odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) associated with age, gender, ethnicity and spherical equivalent were estimated using logistic regression models.

 
Results
 

Among 4040 VIP participants, 505 (12.5%) had astigmatism. Astigmatism was with-the-rule in 428 (84.8%), against-the-rule in 23 (4.6%) and oblique in 54 (10.7%). In multivariate analyses for all types of astigmatism (Table 1), African-American, Hispanic and Asian children were more likely to be astigmatic when compared with Caucasian children (all p<0.02). The OR for myopic children (≤ -1.0 D) relative to emmetropic children was 4.6 (95% CI: 2.9 - 6.8), whereas the OR for hyperopic children (≥ 2.0 D) was 1.3 (95% CI: 1.1 -1.6). The association between spherical equivalent refractive error and astigmatism was not linear (Figure 1). There was a trend of increasing risk of astigmatism with older children (linear trend p=0.12). The analysis for the risk factors of with-the-rule astigmatism provided similar results as all types of astigmatism.

 
Conclusions
 

Among Head Start preschoolers, Hispanic ethnicity, African-American and Asian race, and myopic and hyperopic refractive error were associated with increased risk of astigmatism, consistent with findings from the population-based Multi-ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease studies.

 
 
Table 1 Multivariate Analysis for the Risk Factors of Astigmatism in Preschoolers (N=4040)
 
Table 1 Multivariate Analysis for the Risk Factors of Astigmatism in Preschoolers (N=4040)
 
 
Figure 1: The relationship between spherical equivalent refractive error and the prevalence of astigmatism in preschoolers in VIP study
 
Figure 1: The relationship between spherical equivalent refractive error and the prevalence of astigmatism in preschoolers in VIP study
 
Keywords: 428 astigmatism • 464 clinical (human) or epidemiologic studies: risk factor assessment  
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