June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Choroidal and Retinal Thickness in Patients Affected by Chronic Posterior Uveitis
Author Affiliations & Notes
  • Luisa Pierro
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Marco Gagliardi
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Elisabetta Miserocchi
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Lorenzo Iuliano
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Ingrid Bianchi
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Claudia Del Turco
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Giuseppe Parrinello
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Giulio Modorati
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Maurizio Parodi
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Francesco Bandello
    Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
  • Footnotes
    Commercial Relationships Luisa Pierro, None; Marco Gagliardi, None; Elisabetta Miserocchi, None; Lorenzo Iuliano, None; Ingrid Bianchi, None; Claudia Del Turco, None; Giuseppe Parrinello, None; Giulio Modorati, None; Maurizio Parodi, None; Francesco Bandello, ALLERGAN Inc. (S), NOVARTIS PHARMACEUTICALS CORPORATION (S), FARMILA-THEA (S), BAYER SCHERING PHARMA (S), PFIZER Inc. (S), ALCON Inc. (S), BAUSCH AND LOMB (S), GENENTECH Inc. (S), ALIMERA SCIENCES Inc. (S), SANOFI AVENTIS (S), THROMBOGENICS (S)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5836. doi:
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      Luisa Pierro, Marco Gagliardi, Elisabetta Miserocchi, Lorenzo Iuliano, Ingrid Bianchi, Claudia Del Turco, Giuseppe Parrinello, Giulio Modorati, Maurizio Parodi, Francesco Bandello; Choroidal and Retinal Thickness in Patients Affected by Chronic Posterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5836.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate macular choroidal and retinal thicknesses in patients affected by chronic posterior uveitis treated with systemic anti-inflammatory drugs.

Methods: 71 eyes of 40 consecutive patients with chronic treated posterior uveitis were enrolled. 30 healthy eyes were the control group. Eyes with uveitis were divided into active and non-active groups. Choroidal thickness (CT) was assessed using the Heidelberg Engineering® Spectral domain optical coherence tomography (SDOCT) with the Enhanced Depth Imaging (EDI) scan system at the fovea and up to 1mm at intervals of 0.5mm from the fovea in the superior, inferior, nasal and temporal choroid. Central foveal thickness (CFT) was also measured.

Results: Average CT was 240±76μm in the active group, and 250±66μm in the non-active group. No significant statistical difference in CT was found between pathological eyes with active or non-active uveitis (p=0.3937). CT turned out to be significantly thinner both in active and non-active uveitis eyes respectively compared to controls (290±66μm) (p=0.0043 and p=0.0256 respectively). No statistically significant difference was found between active-uveitis eyes CFT (320±120μm) and controls CFT (280±20μm; p=0.7189), while in non-active eyes it was found to be thinner (250±88μm;p<0.0001) compared to controls. Macular/choroid ratio in active-uveitis eyes (1.5±0.76) was significantly higher than in controls (0.99±0.29; p=0.007), while no statistical differences were found in non-active eyes (0.88±0.38; p=0.2124).

Conclusions: In eyes with chronic active uveitis, the retina appears to be more involved in the inflammatory process than the choroid. In eyes with non-active uveitis, both the retina and the choroid are involved in a similar way.

Keywords: 452 choroid • 688 retina • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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