June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Loss of GCL in HIV positive patients with low (< 100) nadir CD4 counts
Author Affiliations & Notes
  • Frank Verbraak
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, Netherlands
    Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands
  • Nazli Demirkaya
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, Netherlands
  • Michael Abramoff
    University of Iowa, Iowa City, IA
  • Footnotes
    Commercial Relationships Frank Verbraak, None; Nazli Demirkaya, None; Michael Abramoff, IDx LLC (E), IDx LLC (I), University of Iowa (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5837. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Frank Verbraak, Nazli Demirkaya, Michael Abramoff, ; Loss of GCL in HIV positive patients with low (< 100) nadir CD4 counts. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5837.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: In HIV positive patients neurodegeneration is part of the overall co-morbity. Structural loss of neuro-retinal tissue has been described in these patients. We measured the individual retinal layers in search of posssible neuro-retinal degeneration.

Methods: Seventy-two HIV-positive patients were enrolled in this study. All underwent a complete ophthalmological examination. Patients with a history of retinitis or any other disease known to influence the retina were excluded (n=10). Patients were divided in two groups: patients with a nadir CD4 count > 100 (n=40), and patients with a nadir CD4 count less than 100 (n=22). Macular 3D volume OCT scans were made with SD-OCT (Topcon, MarckII), and segmented with custom-build software developed at the University of Iowa. Mean thickness of each individual layer was measured, and compared between both groups.

Results: Of all layers measured the Ganglion Cell Layer (GCL) was the only statistically significant thinner layer in the group of patients with a low nadir CD4 count compared to patients with higher nadir CD4 counts: 31.6 micrometer (+/- 3.4), versus 33.8 micrometer (+/- 3.6), p = 0.03 (Man-Whitney U-test).

Conclusions: HIV-positive patients with a low nadir CD4 count (< 100) have a thinner macular GCL compared to HIV positive patients with higher nadir CD4 counts (>100), demonstrating structural neuro-retinal degeneration, which could be part of a more degeneralized neurodegeneration.

Keywords: 550 imaging/image analysis: clinical • 612 neuro-ophthalmology: diagnosis  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×