June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Association of AJCC pT category with outcome in sebaceous carcinoma of the eyelid
Author Affiliations & Notes
  • Valerie White
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    Ophthalmology and Visual Science, University of British Columbia, Vancouver, BC, Canada
  • Kaustubh Mulay
    Ophthalmic Pathology, LV Prasad Eye Institute, Hyderabad, India
  • Sneha Agrawal
    Oculoplastic and Orbital Surgery, LV Prasad Eye Institute, Hyderabad, India
  • Santosh Honavar
    Oculoplastic and Orbital Surgery, LV Prasad Eye Institute, Hyderabad, India
  • Footnotes
    Commercial Relationships Valerie White, None; Kaustubh Mulay, None; Sneha Agrawal, None; Santosh Honavar, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5890. doi:
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      Valerie White, Kaustubh Mulay, Sneha Agrawal, Santosh Honavar; Association of AJCC pT category with outcome in sebaceous carcinoma of the eyelid. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5890.

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Abstract
 
Purpose
 

The 7th edition of the AJCC classification of ophthalmic tumors is in the process of being validated. Only one previous study has validated the updated classification for sebaceous carcinoma of the eyelid with outcome (Esmaeli B et al. Ophthalmology 2012; 119:1078-82) We wanted to perform a validation study from another global region.

 
Methods
 

The medical records and pathology slides of all patients treated in the Oculoplastic and Oncology Department of LV Prasad Eye Institute with a diagnosis of sebaceous carcinoma of the eyelid from 2001 to 2011 were retrieved. The slides were reviewed for diagnosis, type of specimen, size and spread of tumor, and margins of excision. The following clinical information was extracted: age, sex, previous occurrence prior to presentation at LVPEI, treatment, recurrences, lymph node and/or distant metastases.

 
Results
 

242 pathology specimens from 197 patients were examined. Only 54 patients had adequate follow-up for analysis. There were 35 women and 19 men with a mean age of 56 years. The following table shows the number of patients in each pT category and the relationship of pT category to local recurrence and metastases.

 
Conclusions
 

Follow-up was difficult to obtain in this setting. However, as most patients were treated by surgery and have a pathologic specimen, a pT category could be applied and predicted increasing incidence of local recurrence, and local and distant metastases. A source of uncertainty was whether to classify those patients with predominantly in-situ disease that had been treated by exenteration as Tis or T3b.

 
 
Correlation of pT category with outcome in sebaceous carcinoma of the eyelid
 
Correlation of pT category with outcome in sebaceous carcinoma of the eyelid
 
Keywords: 744 tumors • 526 eyelid • 638 pathology: human  
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