June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Conjunctival Nevus: Clinicopathological Review of 724 cases
Author Affiliations & Notes
  • Stephanie De la O-Pérez
    Ophthalmic Pathology Service, Hospital "Dr. Luis Sánchez Bulnes", Asociación Para Evitar la Ceguera en México,, Mexico city, Mexico
  • Héctor Rodríguez-Martínez
    Anatomopathological Research Laboratory "Roberto Ruiz Obregón” Experimental Medicine Department, Medical Faculty, National Autonomous University of Mexico, General Hospital of Mexico, Mexico City, Mexico
  • Dolores Ríos y Valles-Valles
    Ophthalmic Pathology Service, Hospital "Dr. Luis Sánchez Bulnes", Asociación Para Evitar la Ceguera en México,, Mexico city, Mexico
  • Ofelia Pérez-Olvera
    Anatomopathological Research Laboratory "Roberto Ruiz Obregón” Experimental Medicine Department, Medical Faculty, National Autonomous University of Mexico, General Hospital of Mexico, Mexico City, Mexico
  • Alfredo Gómez-Leal
    Ophthalmic Pathology Service, Hospital "Dr. Luis Sánchez Bulnes", Asociación Para Evitar la Ceguera en México,, Mexico city, Mexico
  • Armando Medina-Cruz
    Anatomopathological Research Laboratory "Roberto Ruiz Obregón” Experimental Medicine Department, Medical Faculty, National Autonomous University of Mexico, General Hospital of Mexico, Mexico City, Mexico
  • María del Mar Namba-Bando
    Ophthalmic Pathology Service, Hospital "Dr. Luis Sánchez Bulnes", Asociación Para Evitar la Ceguera en México,, Mexico city, Mexico
  • Luis De La O-Cerna
    Eye Bank, University Hospital, Autonomous University of Coahuila, Torreón, Mexico
  • Abelardo Rodríguez-Reyes
    Ophthalmic Pathology Service, Hospital "Dr. Luis Sánchez Bulnes", Asociación Para Evitar la Ceguera en México,, Mexico city, Mexico
  • Footnotes
    Commercial Relationships Stephanie De la O-Pérez, None; Héctor Rodríguez-Martínez, None; Dolores Ríos y Valles-Valles, None; Ofelia Pérez-Olvera, None; Alfredo Gómez-Leal, None; Armando Medina-Cruz, None; María del Mar Namba-Bando, None; Luis De La O-Cerna, None; Abelardo Rodríguez-Reyes, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5895. doi:
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      Stephanie De la O-Pérez, Héctor Rodríguez-Martínez, Dolores Ríos y Valles-Valles, Ofelia Pérez-Olvera, Alfredo Gómez-Leal, Armando Medina-Cruz, María del Mar Namba-Bando, Luis De La O-Cerna, Abelardo Rodríguez-Reyes; Conjunctival Nevus: Clinicopathological Review of 724 cases. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5895.

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Abstract
 
Purpose
 

Present clinicopathological characteristics of Conjuntival Nevus (CN) in a Mexican population.

 
Methods
 

All surgically excised cases with histopathological diagnosis of CN were collected form the Ophthalmic Pathology Service archives at a referral center in Mexico City over a period of 54 years (1957-2011). Clinical and demographical data were obtained from clinical charts. All slides were reviewed and reclassified.

 
Results
 

From a total of 777 cases, 724 were confirmed as CN. Prevalence in women was 54% compared to 46% in men, with a mean age of 23 (SD 18) years at the time of surgical excision (range, 6 months - 85 years). In 52% of the cases, the left eye (OS) was affected, compared to 48% in the right eye (OD). The vast majority were located on bulbar conjunctiva (67%). The average size was 4 mm (SD 2, range, 0.5mm - 15mm). Most of the CN were observed clinically as flat lesions (91%). Histopathologically, 87% were compound, 12% subepithelial and 1% intraepithelial nevus. Inclusion cysts were present in 73% of the cases. Melanin was observed in all cases, 95% in nevus cells and 93% in melanophages. Accompanying inflammatory infiltrate was observed 62% of the time, 32% presented eosinophils. Melanosis (26%) and hypervascularity (27%) were associated features. Five cases corresponded to balloon cell type nevus.

 
Conclusions
 

CN in Mexican population occur in young individuals, slightly more in women than in men, both eyes affected equally. Mostly apparent as a flat pigmented lesion in the bulbar conjunctiva. Compound nevus is the most frequent type, very often associated with inclusion cysts; an inflammatory component is present in more than half the cases. The balloon cell nevus is rare in this location. To the best of our knowledge, this is the largest series of CN until now presented.

 
 
Classical clinical appearance of a nevus: flat pigmented lesion in bulbar conjunctiva.
 
Classical clinical appearance of a nevus: flat pigmented lesion in bulbar conjunctiva.
 
 
Compound nevus.
 
Keywords: 474 conjunctiva • 638 pathology: human • 744 tumors  
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