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John Hernandez, Carlos Felipe Castaño, Liliana Zuluaga, Gloria Salazar, Eddy Monsalve, Jorge Donado, ; BREASTFEEDING AS A PROTECTIVE FACTOR FOR RETINOPATHY OF PREMATURITY: A CASE-CONTROL STUDY. Invest. Ophthalmol. Vis. Sci. 2013;54(15):600.
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To determine the association between retinopathy of prematurity and breastfeeding as a protective factor.
We included 107 infants from Clínica Universitaria Bolivariana Retinopathy of Prematurity program a , during the years 2009 and 2010. The sample consisted of preterm infants below 32 weeks and birth weight of 1800 grams or less. We recorded the presence and stage of ROP, the type of feeding (breastfeeding vs. formula milk) and related variables.
The incidence of ROP was significantly higher in prematures who received formula during their hospital stay 57.94 ml / day (95% CI: 10.9 to 104.99) (p = 0.01). There was a trend toward lower incidence of ROP in the group of patients who received breast-feeding, but it was not statistically significant. In the bivariate analysis, factors that showed significant association with ROP were: gestational age (OR -2.34, 95% CI: -3.45 to -1.24) (p = 0.00), low birth weight (OR: -306.78 95% CI: -432.8 to -180.76) (p = 0.00), oxygen (OR: 28.52, 95% CI: 14.40 to 42.65) (p = 0.00), blood transfusions (OR: 17.75, 95% CI: 7.73 to 27.76) (p = 0.00), jaundice (OR: 8.4, 95% CI: 1.88 to 38.95) (p = 0.00), intraventricular hemorrhage (OR: 3.89, 95% CI: 0.93 to 16.14) (p = 0.03), and hyaline membrane disease (OR: 7.09, 95% CI: 2.03 to 25.31) (p = 0.00).
The preliminary results of this study support breastfeeding as a protective factor for ROP.
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