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Takaaki Inaba, Motoko Kawashima, Akiko Ito, Mitsuhiro Watanabe, Ken Shinmura, Tetsuya Kawakita, Kazuo Tsubota; Change of Tear Secretion in the Lacrimal Glands of High-Fat Diet-Fed C57BL/6J Mice. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6001.
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© ARVO (1962-2015); The Authors (2016-present)
Aging is one of the most important factors for the pathogenesis of dry eye disease. Metabolic syndrome accelerates aging. Although several studies have reported that diabetic patients have an elevated incidence of dry eye disease, the mechanism responsible for dry eyes disease remains unclear.
We investigated the secretion and metabolic changes occurring at 6 months in response to a high-fat diet (HFD).
Tear secretion was decreased by the HFD compared to normal diet at 6 months. Additionally, inflammatory cell infiltration increased in the lacrimal glands of the HFD-fed mice.We also investigated the molecular mechanisms involved including metabolism and aging genes.
The results indicate that aging accelerated by the HFD is related to dry eye.
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