June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Optical quality after instillation of three different eye drops for dry eye
Author Affiliations & Notes
  • Shizuka Koh
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Naoyuki Maeda
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Chikako Ikeda
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
    Research & Development, Rohto Pharmaceutical CO.,LTD, Kyoto, Japan
  • Yoshihiro Takai
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
    Research & Development, Rohto Pharmaceutical CO.,LTD, Kyoto, Japan
  • Hisataka Fujimoto
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Yoshinori Oie
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Takeshi Soma
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Motokazu Tsujikawa
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Kohji Nishida
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Footnotes
    Commercial Relationships Shizuka Koh, Santen, Inc. (R), Johnson & Johnson (R), Topcon (R), Otsuka Pharmaceutical Co. (R); Naoyuki Maeda, Topcon (F), Santen (R), Otsuka (R), Oculus (R), HOYA (R); Chikako Ikeda, Rohto pharmaceutical CO.,LTD. (E); Yoshihiro Takai, Rohto Pharmaceutical Co. Ltd (E); Hisataka Fujimoto, None; Yoshinori Oie, Santen (F), HOYA (F); Takeshi Soma, HOYA corporation (R), Santen Pharmaceutical Co., Ltd (F), Otsuka Pharmaceutical Co., Ltd (F); Motokazu Tsujikawa, Shionogi & Co. (C), Daiichi Sankyo Co. (F), Daiichi Sankyo Co. (R), Santen Co. (R), AMO Co. (R); Kohji Nishida, Alcon (C), Alcon (F), HOYA (F), Senju (F), Pfizer (F), Santen (F), Osaka University (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6005. doi:
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    • Get Citation

      Shizuka Koh, Naoyuki Maeda, Chikako Ikeda, Yoshihiro Takai, Hisataka Fujimoto, Yoshinori Oie, Takeshi Soma, Motokazu Tsujikawa, Kohji Nishida; Optical quality after instillation of three different eye drops for dry eye. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6005.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate the effect of 3% diquafosol ophthalmic solution, 0.3% sodium hyaluronate ophthalmic solution, and 2% rebamipide ophthalmic suspension on forward light scattering and ocular higher-order aberration (HOA).

Methods: We evaluated forward light scattering and ocular HOAs before, immediately, 5, and 10 minutes after instillation of 3 different eye drops in 7 eyes of 7 normal subjects (mean age, 30.1 ± 4.9 years old). Forward light scattering was quantified with the C-Quant stray light meter. (Oculus Optikgerate GmbH, Germany). HOAs were objectively measured for a 4-mm pupil using newly developed aberrometer (Topcon, Tokyo, Japan). The obtained aberration data were analyzed in the central 4-mm diameter for total HOAs up to the sixth-order Zernike polynomials.

Results: Significant change in forward light scattering was noted after instillation of 2% rebamipide ophthalmic suspension and 3% diquafosol ophthalmic solution (P=0.020, 0.023, one way repeated ANOVA, respectively). Increased stray light immediately after rebamipide ophthalmic suspension instillation recovered to the baseline level thereafter (P<0.05), and 3% diquafosol ophthalmic solution significantly increased HOAs 5 minutes after instillation (P<0.05). There was no significant change in forward light scattering after instillation of 0.3% sodium hyaluronate ophthalmic solution (P=0.239). 0.3% sodium hyaluronate ophthalmic solution significantly increased HOA immediately after instillation (P<0.05), whereas there was no significant change in HOAs after instillation of 3% diquafosol ophthalmic solution (P=0.478) and after instillation of 2% rebamipide ophthalmic suspension. (P=0.234).

Conclusions: Quantitative serial measurement of forward light scattering and HOAs showed that the temporal reduction in optical quality may be mainly attributed to increased forward light scattering after instillation of 2% rebamipide ophthalmic suspension and 3% diquafosol ophthalmic solution, and increased HOAs after instillation of high viscosity 0.3% sodium hyaluronate ophthalmic solution in normal subjects.

Keywords: 486 cornea: tears/tear film/dry eye  
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