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Wool Suh, Changwon Kee; The association of single nucleotide polymorphisms in the connective tissue growth factor gene with pseudoexfoliation syndrome/glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6216.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the association between single nucleotide polymorphisms of the connective tissue growth factor (CTGF) gene with pseudoexfoliation (PEX) syndrome/glaucoma in the South Korean population.
Patients with PEX syndrome were recruited and twelve single nucleotide polymorphisms (SNPs; rs6917644, rs9399005, rs2151532, rs928501, rs7768619, rs9388949, rs12192108, rs1475723, rs928505, rs233925, rs170881 and rs9388956) of CTGF were genotyped in genomic DNA extracted by the standard method from leucocytes isolated from the peripheral blood samples of study subjects. The Fisher’s exact test was conducted for genotype frequency.
A total of one hundred and seven PEX syndrome patients, including forty one pseudoexfoliative glaucoma patients, were enrolled in the study. In twelve SNPs, rs2151532 and rs928501 were correlated with PEX syndrome. In particular, rs2151532 was significantly correlated with pseudoexfoliative glaucoma. Other SNPs were not significantly associated with PEX syndrome (P > 0.05).
The rs2151532 and rs928501 SNPs in the CTGF gene were significantly associated with PEX syndrome, and in particular, rs2151532 SNP showed a significant correlation with pseudoexfoliative glaucoma.
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