June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Correlation of clinically undetected macular features by spectral domain OCT and angiography in early stages of retinopathy of prematurity
Author Affiliations & Notes
  • Cynthia Villalobos-Ojeda
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Veronica Giordano
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Samantha Salinas Longoria
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Rafael Romero Vera
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Guillermo Salcedo-Villanueva
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Gerardo Garcia-Aguirre
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Virgilio Morales-Canton
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Hugo Quiroz-Mercado
    Denver health medical center, denver, CO
  • Maria Martinez-Castellanos
    Asociacion para evitar la ceguera, Mexico, Mexico
  • Footnotes
    Commercial Relationships Cynthia Villalobos-Ojeda, None; Veronica Giordano, None; Samantha Salinas Longoria, None; Rafael Romero Vera, None; Guillermo Salcedo-Villanueva, None; Gerardo Garcia-Aguirre, None; Virgilio Morales-Canton, Clearside Biomedical (F); Hugo Quiroz-Mercado, Allegro Pharmaceutical (C); Maria Martinez-Castellanos, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 625. doi:
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      Cynthia Villalobos-Ojeda, Veronica Giordano, Samantha Salinas Longoria, Rafael Romero Vera, Guillermo Salcedo-Villanueva, Gerardo Garcia-Aguirre, Virgilio Morales-Canton, Hugo Quiroz-Mercado, Maria Martinez-Castellanos; Correlation of clinically undetected macular features by spectral domain OCT and angiography in early stages of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2013;54(15):625.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To describe and correlate the fluorescein angiography (FA) and hand held spectral domain optical coherence tomography (HH-SD OCT) macular findings in eyes with stage 1 and 2 ROP with a clinically normal appearing macula.

 
Methods
 

Observational, retrospective case series of infants who underwent routine screening with indirect ophthalmoscopy and imaging under topical anesthesia. Imaging included retinal FA using the Retcam II (Clarity Medical Systems, Pleasanton, CA) and hand held spectral domain OCT imaging with iVue (Optovue, Inc, Freemont, CA)

 
Results
 

We included 12 eyes of 7 infants that were diagnosed with ROP stage 1 or 2 in zones II and III with clinically normal macula, but by angiography presented an abnormal diffuse capillary leakage pattern in the parafoveal area. Mean gestational age at birth was 29.5 weeks (range 26-33 weeks) . Mean postmenstrual age (PMA) was 39.8 weeks (range 34-44 weeks). Retinal FA of the 12 eyes (100%) showed an angiographic diffuse capillary leakage pattern . OCT studies of 3 eyes (25%) showed no macular abnormalities . 9 eyes (75%) presented intraretinal cystoid spaces with preservation of the foveal depression . This findings regressed once the retinal vasculature reached the ora serrata. 3 eyes (25%) presented a probable epiretinal membrane formation.

 
Conclusions
 

Macular abnormalities of premature infant eyes with ROP seen on angiographic or tomographic evaluation might reflect variability in remodeling of foveal architecture during development either neural, vascular or both. The vascular changes could be explained due to parietal leakage because of vascular immaturity, related to the formation and the maturation of the mural cells (perycites). The abnormalities seen by OCT may explain the deficits in acuity, color and visual sensitivity in adulthood. This pilot study provides valuable information of macular findings of patients with mild ROP. A larger series with longer follow up is needed, in order to know if these subtles changes can influence the final macular morphology and visual acuity in adulthood.

 
Keywords: 706 retinopathy of prematurity • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical  
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