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Ulfah Rimayanti, Ken Yamane, Miftahul Akhyar Latief, Hideki Mochizuki, Junko Hirata, Yoshiaki Kiuchi; Inner Retinal Layers Damage in Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6290.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the presence of inner retinal layers damage in age-related macular degeneration (AMD)
One hundred and thirty three eyes with AMD and 72 normal eyes were included in this study. All subjects underwent ophthalmological examination including best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure measurement, color fundus photograph. Fluorescein angiography and indocyanine green angiography examinations were performed on eyes with AMD. Ganglion Cell Complex (GCC) parameters (GCC average, superior, and inferior thickness, focal loss volume (FLV), global loss volume (FLV), and retinal nerve fiber layer (RNFL) thickness were measured using RTVue Spectral Domain Optical Coherence Tomography. The independent-samples t-test was used to compare the GCC parameters and RNFL thickness between AMD and normal eyes. One-way ANOVA was used to examine the relationships between treatment types (untreated, treated only with anti-vascular endothelial growth factor (VEGF), treated only with photodynamic therapy, combined therapy) and GCC parameters changes. The Spearman`s correlation test was used to determine the relationships between BCVA, duration of AMD and GCC parameters, RNFL thickness.
There were significant decreased of GCC average, superior, and inferior thickness in eyes with AMD compared to normal eyes (all p<0.0001). As for the FLV and GLV, there were significant increased (all p<0.0001). There were no significant changes in RNFL average, superior, and inferior thickness. Furthermore, there were no relationships between treatment types and duration of disease to GCC parameters changes. In addition, there were significant negative correlations between FLV and BCVA, GLV and BCVA in eyes with AMD.
These findings indicated the presence of inner retinal layers damage in eyes with AMD, and it was not influenced by therapy.
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