June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Microbial spectrum of endophthalmitis following intravitreal injection versus pars plana vitrectomy
Author Affiliations & Notes
  • Michael Dollin
    Wills Eye Institute, Philadelphia, PA
  • Philip Storey
    Wills Eye Institute, Philadelphia, PA
  • John Pitcher
    Wills Eye Institute, Philadelphia, PA
  • James Vander
    Wills Eye Institute, Philadelphia, PA
  • Jason Hsu
    Wills Eye Institute, Philadelphia, PA
  • Sunir Garg
    Wills Eye Institute, Philadelphia, PA
  • Footnotes
    Commercial Relationships Michael Dollin, None; Philip Storey, None; John Pitcher, None; James Vander, None; Jason Hsu, None; Sunir Garg, Lux (F), EyeGate (F), Regeneron (F), Genentech (F), Allergan (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6310. doi:
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    • Get Citation

      Michael Dollin, Philip Storey, John Pitcher, James Vander, Jason Hsu, Sunir Garg; Microbial spectrum of endophthalmitis following intravitreal injection versus pars plana vitrectomy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6310.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To compare causative organisms in endophthalmitis following intravitreal injection (IVI) to endophthalmitis following pars plana vitrectomy (PPV).

Methods: Retrospective review of all available bacterial cultures in patients who developed endophthalmitis following IVI or PPV between January 1, 2009, and October 1, 2012, from one large vitreoretinal practice. Data were analyzed using Fisher’s exact test (two-tailed).

Results: Bacterial cultures from 34 cases of endophthalmitis following IVI, and 17 cases of endophthalmitis following PPV, were reviewed. In the IVI group, 14 cases (41.2%) were culture positive. Seven of these cases showed growth of bacteria associated with oral flora: Streptococcus viridans, Streptococcus mitis, Streptococcus salivarius, Streptococcus sanguinis, Enterococcus faecalis (2 cases), and Lactobacillus. In the PPV group, 8 cases (47.1%) were culture positive. The most common organisms in this group were Staph species, and none of the cultures grew bacteria associated with oral flora. Patients who developed endophthalmitis after IVI were significantly more likely than patients developing endophthalmitis after PPV to grow bacteria associated with oral flora (P = 0.023).

Conclusions: Endophthalmitis following IVI has a higher likelihood of being due to oral flora compared to endophthalmitis following PPV. Caution should be taken to avoid introduction of oral flora onto the eye during IVI.

Keywords: 513 endophthalmitis • 561 injection • 762 vitreoretinal surgery  

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