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Takushi Kawamorita, Hiroshi Uozato, Hiroshi Sasaki, Yuko Shibata, Masatsugu Kanazawa, Masakazu Hirota, yoona jang, Shinji Arai, Kimiya Shimizu; Schematic eye model based on the regression of age-dependent changes of the crystalline lens. Invest. Ophthalmol. Vis. Sci. 2013;54(15):848.
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© ARVO (1962-2015); The Authors (2016-present)
To construct a schematic eye model based on the regression of age-dependent changes of the crystalline lens and determine the effects on retinal image quality of refractive index, transmittance, scattering, and lens shape.
Optical simulation was performed using the optical design software CodeV. Three-dimensional eye models based on a modified Navarro model eye were used for the simulation. We used a number of published regression models in relation to the shape and optical characteristics of crystalline lens used. Refractive error and modulation transfer function (MTF) were calculated.
With increasing refractive index of the lens nucleus (from 0 to +0.02), refractive errors showed a myopic shift (from 0 to -8.50 D). The amount of change increased in as the lens nucleus became steeper. However, with increasing refractive index of the lens cortex, refractive errors showed a hyperopic shift (from 0 to +2.33 D). As scattering angle increased (from 0 to 30 min arc), MTF decreased overall and the lens nucleus was affected the most. As transmittance at the center of the lens decreased (from 100 to 10%), MTF was increased at 250 c/mm and decreased at 100 c/mm, indicating the effect of apodization.
This schematic eye model based on regression of age-dependent changes of the crystalline lens should prove useful for the comparative evaluation of refractive correction methods and the development of new ophthalmic instruments.
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