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MANSOUR F. ARMALY, K. R. RAO; The Effect of Pilocarpine Ocusert With Different Release Rates on Ocular Pressure. Invest. Ophthalmol. Vis. Sci. 1973;12(7):491-496.
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The pilocarpine-Ocusert system exhibits a dose-effect relationship such that a greater release rate results in a greater ocular hypotensive effect; the effect is not appreciably modified when release rates are in excess of 50 µg per hour. The magnitude of the mean per cent reduction in outflow pressure with 50 µg per hour is comparable to that reported for pilocarpine concentrations of 4 to 8 per cent. The hypotensive effect of Ocusert-50 is significantly greater than that of pilocarpine 2 per cent ophthalmic solution. Clinically, a single Ocusert unit can maintain controlled ocular pressure level in the sensitive individual for 2 to 4 days, and this control seems to increase with the release rate.
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