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E H Bárány; Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment.. Invest. Ophthalmol. Vis. Sci. 1975;14(4):302-306.
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Accommodative responses to intramuscular pilocarpine were determined in four surgically aniridic vervet monkeys, before and after eight weeks of daily unilateral topical treatment with echothiophate iodide. The echothiophate-treated eyes maintained maximum myopia during the treatment course. However, after echotiophate treatment was stopped and the refraction had returned to baseline, a subsensitivity of the accommodative mechanism to pilocarpine became apparent. Normal sensitivity to pilocarpine did not return until four to five months after echothiophate treatment had been stopped.
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