April 1975
Volume 14, Issue 4
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Articles  |   April 1975
Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment.
Investigative Ophthalmology & Visual Science April 1975, Vol.14, 302-306. doi:
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      E H Bárány; Subsensitivity to pilocarpine in primate ciliary muscle following topical anticholinesterase treatment.. Invest. Ophthalmol. Vis. Sci. 1975;14(4):302-306.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Accommodative responses to intramuscular pilocarpine were determined in four surgically aniridic vervet monkeys, before and after eight weeks of daily unilateral topical treatment with echothiophate iodide. The echothiophate-treated eyes maintained maximum myopia during the treatment course. However, after echotiophate treatment was stopped and the refraction had returned to baseline, a subsensitivity of the accommodative mechanism to pilocarpine became apparent. Normal sensitivity to pilocarpine did not return until four to five months after echothiophate treatment had been stopped.

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