November 1977
Volume 16, Issue 11
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Articles  |   November 1977
Ocular abnormalities in the myopathic hamster (UM-X7.1 strain).
Investigative Ophthalmology & Visual Science November 1977, Vol.16, 1047-1052. doi:
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      J H Thakar, D H Percy, K P Strickland; Ocular abnormalities in the myopathic hamster (UM-X7.1 strain).. Invest. Ophthalmol. Vis. Sci. 1977;16(11):1047-1052.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Eyes from cardiomyopathic hamsters (UM-X7.1 strain) were examined histologically for evidence of ocular defects. Changes observed included microphthalmia, scleral ectasia, scleral rupture, keratoconus, retinal detachment, retinal dysplasia, retinal fragmentation, retinal thinning, fibrosis of iris and ciliary body, ectopia lentis, and cataract formation. Lesions characteristic of cardiomyopathic hamsters were observed in the myocardium and skeletal muscle. This strain may be a suitable animal model to study the pathogenesis of ocular changes seen in certain congenital connective tissue disorders in man.

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