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H N Fukui, S Iwata, D L Epstein, L O Merola; Cataractogenic effects of a boron hydride disulfide compound.. Invest. Ophthalmol. Vis. Sci. 1977;16(7):654-657.
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The disulfide form but not the sulfhydryl form of a boron hydride compound was found to be cataractogenic. Apparently this compound attaches to the sulfhydryl group of Na-K ATPase in the lens epithelium inactivating this crucial enzyme. The consequence is that a defect in the cation pump activity arises, leading to a rapid influx of Na ions and loss of K ions and marked increase in hydration. These changes are thought to lead to opacification.
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