July 1977
Volume 16, Issue 7
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Articles  |   July 1977
Corneal transplantation reaction in avascular keratoconus patients due to HLA-associated immune aberration against infection. A hypothesis.
Investigative Ophthalmology & Visual Science July 1977, Vol.16, 644-646. doi:
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      S Vannas, A Vannas, A Tilikainen; Corneal transplantation reaction in avascular keratoconus patients due to HLA-associated immune aberration against infection. A hypothesis.. Invest. Ophthalmol. Vis. Sci. 1977;16(7):644-646.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

HLA-B12 and HLA-B27 appeared to be characteristic of avascular keratoconus patients at risk of developing a corneal allograft reaction, which was mainly of late type and triggered by a nasopharyngeal infection. Equally incompatible grafts to patients with HLA-B5 had an uneventful course. This may be inference to the role of HLA-associated immune resistance factors, which necessitate the search for histocompatible corneal grafts also for avascular recipients bearing such indicators of risk.

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