October 1977
Volume 16, Issue 10
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Articles  |   October 1977
Specific glucocorticoid receptor in the iris--ciliary body of the rabbit.
Investigative Ophthalmology & Visual Science October 1977, Vol.16, 973-976. doi:
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      B I Weinstein, K Altman, G G Gordon, M Dunn, A L Southren; Specific glucocorticoid receptor in the iris--ciliary body of the rabbit.. Invest. Ophthalmol. Vis. Sci. 1977;16(10):973-976.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The cytoplasm of the iris--ciliary body of the rabbit contains a receptor capable of specifically binding dexamethasone. This binding protein has a high affinity for dexamethasone (average KD = 2.0 X 10(-8) M), a low capacity (average 4.8 X 10(-13) mol of steroid bound per milligram of protein), and extreme heat sensitivity; it exhibits a pattern of competition virtually identical to that obtained with glucocorticoid receptors from other tissues and shows characteristic physicochemical behavior in various salt concentrations. The demonstration of a specific dexamethasone receptor in the iris--ciliary body provides the first direct biochemical evidence that these tissues may function as a target organ for glucocorticoids.

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