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B Oakley, R H Steinberg, S S Miller, S E Nilsson; The in vitro frog pigment epithelial cell hyperpolarization in response to light.. Invest. Ophthalmol. Vis. Sci. 1977;16(8):771-774.
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Pigment epithelial cell membrane potentials were measured in an in vitro frog retina-pigment epithelium-choroid preparation. Light stimuli hyperpolarized the apical membrane of the pigment epithelium. This hyperpolarization was the source of the c-wave of the electroretinogram. Light stimuli also decreased retinal extracellular potassium ion concentration, [K+]O, with the same time course as the apical hyperpolarization. It is suggested that the pigment epithelial hyperpolarization, which causes the c-wave, results directly from the light-evoked decrease in retinal [K+]O.
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