June 1977
Volume 16, Issue 6
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Articles  |   June 1977
Effect of vidarabine and related compounds on corneal endothelium.
Investigative Ophthalmology & Visual Science June 1977, Vol.16, 545-549. doi:
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      D S Hull, K Bowman, K Green; Effect of vidarabine and related compounds on corneal endothelium.. Invest. Ophthalmol. Vis. Sci. 1977;16(6):545-549.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The endothelial surface of rabbit corneas was perfused with vidarabine monophosphate (with and without adenosine deaminase inhibitor), vidarabine (with and without adenosine deaminase inhibitor), and ara-Hx. In concentrations 10 times to 1,500 times higher than those that have been obtained in the aqueous humor following topical, subconjunctival, or systemic administration, none of the compounds had any effect on corneal endothelial cell function or ultrastructure for the duration of the experimental model.

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