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V L Weimar; Activation of initial wound healing responses in rat corneas in organ culture by mesodermal growth factor.. Invest. Ophthalmol. Vis. Sci. 1979;18(5):532-535.
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In organ culture, mesodermal growth factor (MGF) from mouse submaxillary glands stimulates fibroblast formation, mitosis, and migration of cells into the dead-cell zone adjacent to the wound edge of rat corneal buttons. A classic dose-response relationship between the width of the stromal fibroblast zone and the dose of MGF suggests that fibroblast zone width may be used as a measure for screening agents which influence the initial stages of corneal wound healing.
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