May 1979
Volume 18, Issue 5
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Articles  |   May 1979
Activation of initial wound healing responses in rat corneas in organ culture by mesodermal growth factor.
Investigative Ophthalmology & Visual Science May 1979, Vol.18, 532-535. doi:
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      V L Weimar; Activation of initial wound healing responses in rat corneas in organ culture by mesodermal growth factor.. Invest. Ophthalmol. Vis. Sci. 1979;18(5):532-535.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

In organ culture, mesodermal growth factor (MGF) from mouse submaxillary glands stimulates fibroblast formation, mitosis, and migration of cells into the dead-cell zone adjacent to the wound edge of rat corneal buttons. A classic dose-response relationship between the width of the stromal fibroblast zone and the dose of MGF suggests that fibroblast zone width may be used as a measure for screening agents which influence the initial stages of corneal wound healing.

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