April 1984
Volume 25, Issue 4
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Articles  |   April 1984
Human interferon alpha A or alpha D and trifluridine treatment for herpetic keratitis in rabbits.
Investigative Ophthalmology & Visual Science April 1984, Vol.25, 480-483. doi:
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      M D Trousdale, A B Nesburn; Human interferon alpha A or alpha D and trifluridine treatment for herpetic keratitis in rabbits.. Invest. Ophthalmol. Vis. Sci. 1984;25(4):480-483.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Recombinant human interferon (IFN) alpha A and alpha D combined with 1% trifluridine ophthalmic solution gave beneficial results when applied topically at a dose of 1 x 10(6) U per eye four times a day commencing 4 hr after eyes were inoculated with herpes simplex virus (HSV-1). Acute herpetic keratitis was suppressed by trifluridine alone and the combined therapies, but the high-titered interferon preparations, alone, had little effect. Duration of HSV-1 shedding into tear film during topical treatment for acute herpetic keratitis was reduced slightly by combined therapy with either IFN alpha A or IFN alpha D with trifluridine.

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