June 1984
Volume 25, Issue 6
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Articles  |   June 1984
The photodynamic effect of chlorpromazine, promazine, and hematoporphyrin on lens protein.
Investigative Ophthalmology & Visual Science June 1984, Vol.25, 746-750. doi:
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      J E Roberts; The photodynamic effect of chlorpromazine, promazine, and hematoporphyrin on lens protein.. Invest. Ophthalmol. Vis. Sci. 1984;25(6):746-750.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Calf lens protein was irradiated with near ultraviolet (UV) light in the presence of the drugs chlorpromazine, promazine, and hematoporphyrin. It then was analyzed by SDS-polyacrylamide gel electrophoresis and amino acid analysis. Marked increases in protein photopolymerization (other than S-S bond formation) and histidine destruction were noted in the presence of these drugs. In all cases, these effects were reduced in the presence of a singlet oxygen quencher, thus suggesting that these photodynamic effects are due, at least in part, to a Type II mechanism.

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