December 1987
Volume 28, Issue 12
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Articles  |   December 1987
Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye.
Author Affiliations
  • Y Kuwayama
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia 19104-6075.
  • R A Stone
    Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia 19104-6075.
Investigative Ophthalmology & Visual Science December 1987, Vol.28, 1947-1954. doi:
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      Y Kuwayama, R A Stone; Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in the guinea pig eye.. Invest. Ophthalmol. Vis. Sci. 1987;28(12):1947-1954.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Using a double labeling indirect immunofluorescent technique, we studied the guinea pig trigeminal ganglion and eye for co-localization of substance P and calcitonin gene-related peptide. In the trigeminal ganglion, the number of neurons immunoreactive for calcitonin gene-related peptide significantly outnumber those immunoreactive for substance P, but virtually all substance P positive neurons are immunoreactive for calcitonin gene-related peptide. In the eye, a complex pattern of co-localization is present; both peptides co-localize in most immunoreactive nerve fibers. Nerve fibers immunoreactive only for calcitonin gene-related peptide tend to be concentrated in the cornea and posterior ciliary body. Nerve fibers immunoreactive only for substance P are present in relation to both iris muscles. Sensory denervation by intracranial transection of the ophthalmic and maxillary nerves fails to eliminate these substance P positive but CGRP negative iris nerve fibers. These findings indicate an alternative origin for substance P immunoreactive nerves supplying the iris muscles in this species.

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