October 1987
Volume 28, Issue 10
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Articles  |   October 1987
Parasympathetic denervation hypersensitivity of the iris in ocular hypertension.
Author Affiliations
  • C V Clark
    Glaucoma Unit, St. Paul's Eye Hospital, Liverpool, United Kingdom.
  • R Mapstone
    Glaucoma Unit, St. Paul's Eye Hospital, Liverpool, United Kingdom.
Investigative Ophthalmology & Visual Science October 1987, Vol.28, 1732-1735. doi:
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      C V Clark, R Mapstone; Parasympathetic denervation hypersensitivity of the iris in ocular hypertension.. Invest. Ophthalmol. Vis. Sci. 1987;28(10):1732-1735.

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Abstract

Seventy-eight ocular hypertensive patients and 47 age-and sex-matched control subjects were assessed for parasympathetic denervation hypersensitivity of the iris using topical application of 2.5% methacholine chloride solution. Constriction of the pupil in response to methacholine stimulation of the sphincter pupillae was significantly greater in the ocular hypertensive patients than the control group (P less than 0.001). The implications are discussed, with particular reference to the association between autonomic neuropathy and the primary glaucomas.

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