October 1987
Volume 28, Issue 10
Free
Articles  |   October 1987
HLA-DR+/T6- Langerhans cells of the human cornea.
Author Affiliations
  • S K Seto
    Corneal Disease Research Laboratory, Swedish Hospital Medical Center, Seattle, Washington.
  • T E Gillette
    Corneal Disease Research Laboratory, Swedish Hospital Medical Center, Seattle, Washington.
  • J W Chandler
    Corneal Disease Research Laboratory, Swedish Hospital Medical Center, Seattle, Washington.
Investigative Ophthalmology & Visual Science October 1987, Vol.28, 1719-1722. doi:
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      S K Seto, T E Gillette, J W Chandler; HLA-DR+/T6- Langerhans cells of the human cornea.. Invest. Ophthalmol. Vis. Sci. 1987;28(10):1719-1722.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

We have investigated normal human corneas for the presence of T6-marker on Langerhans cells. With the exception of one pair of newborn corneas and two pairs of very young infant corneas, all HLA-DR-positive cells in central and peripheral corneal epithelium were T6-negative by double-labeled immunofluorescence. In contrast, epidermal sheets from normal human eyelid skin displayed positive staining for T6 on most of the HLA-DR-positive Langerhans cells. Since T6 antigen is considered to be a specific Langerhans cell differentiation marker, we interpret this finding to indicate a nonactivated or undifferentiated state of Langerhans cells in normal human corneas.

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