July 1987
Volume 28, Issue 7
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Articles  |   July 1987
Chemotaxis of rat retinal glia to growth factors found in repairing wounds.
Investigative Ophthalmology & Visual Science July 1987, Vol.28, 1092-1099. doi:
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      A K Harvey, F Roberge, L M Hjelmeland; Chemotaxis of rat retinal glia to growth factors found in repairing wounds.. Invest. Ophthalmol. Vis. Sci. 1987;28(7):1092-1099.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Retinal glia migrate to sites in the vitreous body and on the inner and outer surfaces of the retina during a wide variety of pathological processes. Using in vitro cultures of rat retinal glia, we have evaluated an extensive list of homogeneous, well-characterized growth factors as chemoattractants for these cells. Humoral growth factors, fibroblast growth factors, extracellular matrix proteins and immune system cytokines all were without activity except for the platelet-derived growth factor (PDGF). Extracts of bovine ocular tissues including vitreous body and retina yielded significant activity.

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