July 1987
Volume 28, Issue 7
Free
Articles  |   July 1987
Genetic regulation of light damage to photoreceptors.
Investigative Ophthalmology & Visual Science July 1987, Vol.28, 1043-1048. doi:
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      M M LaVail, G M Gorrin, M A Repaci, L A Thomas, H M Ginsberg; Genetic regulation of light damage to photoreceptors.. Invest. Ophthalmol. Vis. Sci. 1987;28(7):1043-1048.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Albino mice of different inbred strains have been exposed to constant fluorescent lighting at an illuminance level of 115-130 ft-c for intervals of 1-6 weeks. Under these conditions the photoreceptors in retinas of albino BALB/cByJ mice rapidly degenerate, whereas the photoreceptors in retinas of albino C57BL/6J-c2J mice are remarkably more resistant to light damage. F1 heterozygotes produced from these two strains display an intermediate degree of light-induced degeneration. These findings demonstrate that phenotypically identical populations with different genetic constitutions can show markedly different sensitivities to light, and that genetic factors must now be included as a determinant for the severity of light damage.

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