November 1987
Volume 28, Issue 11
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Articles  |   November 1987
Basic fibroblast growth factor is present in cultured human retinoblastoma cells.
Author Affiliations
  • L Schweigerer
    Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
  • G Neufeld
    Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
  • D Gospodarowicz
    Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
Investigative Ophthalmology & Visual Science November 1987, Vol.28, 1838-1843. doi:
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      L Schweigerer, G Neufeld, D Gospodarowicz; Basic fibroblast growth factor is present in cultured human retinoblastoma cells.. Invest. Ophthalmol. Vis. Sci. 1987;28(11):1838-1843.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cultured human retinoblastoma cells express the basic fibroblast growth factor (bFGF) gene and they produce material similar, if not identical, to bFGF. The retinoblastoma-derived bFGF can stimulate the proliferation of capillary endothelial cells and this process is inhibited by anti-bFGF antibodies. It is conceivable that the retinoblastoma-derived bFGF contributes to the neovascularization of retinoblastomas.

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