October 1987
Volume 28, Issue 10
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Articles  |   October 1987
Cysteamine induces cataracts in newborn rats.
Author Affiliations
  • T Truong
    Neurology Service, VA Medical Center, San Francisco, California 94121.
  • S M Sagar
    Neurology Service, VA Medical Center, San Francisco, California 94121.
  • W J Millard
    Neurology Service, VA Medical Center, San Francisco, California 94121.
  • J L Shaw
    Neurology Service, VA Medical Center, San Francisco, California 94121.
Investigative Ophthalmology & Visual Science October 1987, Vol.28, 1710-1713. doi:
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      T Truong, S M Sagar, W J Millard, J L Shaw; Cysteamine induces cataracts in newborn rats.. Invest. Ophthalmol. Vis. Sci. 1987;28(10):1710-1713.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Daily subcutaneous injections of cysteamine (CSH) administered to neonatal rats for 6 to 11 days cause dense bilateral cataracts that are evident at eye opening and that are permanent. CSH has been previously shown to induce protein cross-linking by the formation of abnormal disulfide bonds. It is hypothesized that the same mechanism underlies its cataractogenic effect; as such, CSH may be a useful agent in the study of models of senile cataract formation in humans.

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